FREMS, is an abbreviation of ‘Frequency Rhythmic Electrical Modulation System’, also called Lorenz therapy. It utilises an electric neurostimulation therapy featuring a modulated (constantly changing) electrical signal. The methodology was developed by Lorenz Lifetech of Italy. Using the APTIVA® system, a series of two-phase, asymmetricaly balanced electric pulses are delivered via dedicated transcutaneous disposable electrodes placed along the pathway of the nerve involved in the neuropathy.